TRIM25 in Septic Patients

Shanghai Jiao Tong University

Status: Invitation-only

Conditions: Sepsis

Treatments: Diagnostic Test: Gene and Inflammatory Marker Analysis in Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT07320638

Sepsis-2021-278

81900073 (Other Grant/Funding Number)

Details and patient eligibility

About

Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, which can lead to organ damage and failure. The goal of this observational study is to better understand the underlying biological changes that occur in patients with sepsis compared to those who do not have the condition.

We will collect peripheral blood samples from patients diagnosed with sepsis and from non-sepsis control participants. From these samples, we will isolate peripheral blood mononuclear cells (PBMCs) and serum.

We will then analyze these components to measure the activity of specific genes and the levels of key inflammatory factors (cytokines).

The information we gather will help researchers identify molecular and inflammatory markers associated with sepsis. This knowledge is crucial for developing new and more effective methods for diagnosing and treating this critical illness.

Enrollment: 65 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1. SOFA score >=2; 2. Aged 18-70 years male and female; 3. Hospitalization.

Exclusion criteria

• 1. Immune system disease, such as HIV; 2. Disease that possibly affect the function of immune system, such as tumor and chronic viral infection; 3. Patients that treated with massive cortical hormone (>200mg/d) or immunosuppressant; 4. Pregnant or lactation women.

Trial design

65 participants in 1 patient group

Non-sepsis patients

Description:

Sepsis patients

Treatment:

Diagnostic Test: Gene and Inflammatory Marker Analysis in Sepsis