Triple EIT (Electrical Impedance Tomography)

University of Colorado Denver (CU Denver)

Status: Enrolling

Conditions: Cardiopulmonary; Neonates and Preterm Infants

Treatments: Device: Electrical impedance tomography (EIT)

Study type: Observational

Funder types: Other

Identifiers

NCT07247474

25-1298

Details and patient eligibility

About

This study plans to learn more about ways to look at participant's lungs using new machines called Electrical Impedance Tomography (EIT). The EIT does not use harmful radiation like CT or x-ray. It is read through electrodes like using EKG reading heartbeats.

The investigators want to compare the results of patients who have chronic respiratory disease to patients without chronic respiratory disease to learn more about lung structure and composition.

Enrollment: 140 estimated patients

Sex: All

Ages: 2 weeks to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 2 weeks to 25 years of age

• evidence of cardiopulmonary disease including, but not limited to:

  1. Post-prematurity respiratory disease
  2. Congenital diaphragmatic hernia
  3. Pulmonary Hypertension
  4. Congenital heart disease
  5. Respiratory failure
  6. Neuromuscular Disease
  7. Developmental or congenital lung disease

OR matched healthy controls (born at term gestation (>36 weeks gestational age) with no cardiopulmonary disease)

Exclusion criteria

• <2 weeks of age
• Anything that interferes with lead placement on the chest wall (such as, dermatologic conditions, multiple chest tubes, anatomic abnormality, or large dressings that cannot be moved)
• No informed consent
• Pregnant or lactating
• Pacemaker or other metal intrathoracic surgical implant (causes noise in the data)

Trial design

140 participants in 2 patient groups

Cardiopulmonary disease

Description:

Have evidence of cardiopulmonary disease including, but not limited to: * Post-prematurity respiratory disease * Congenital diaphragmatic hernia * Pulmonary hypertension * Congenital heart disease * Respiratory failure * Neuromuscular disease * Developmental or congenital lung disease May be imaged with two machines

Treatment:

Device: Electrical impedance tomography (EIT)

Control

Description:

matched healthy controls with no cardiopulmonary disease

Treatment:

Device: Electrical impedance tomography (EIT)