Troponin T in Chronic Obstructive Pulmonary Disease (COPD) Patients After Physical Exercise

LHL Helse

Status: Completed

Conditions: Myocardial Diseases; COPD

Treatments: Device: Treadmill exercise test

Study type: Interventional

Funder types: Other

Identifiers

NCT02721693

2016/23140

Details and patient eligibility

About

The primary purpose of the study is to investigate if physical exercise is associated with myocardial damage, expressed by elevated troponin T, in patients with COPD.

Full description

Patients with COPD will perform a cardiopulmonary exercise test (CPET) on treadmill until exhaustion, 8-12 minutes. Venous blood will be drawn before exercise test and 15 minutes, 3 hours and 24 hours after test for analysis of high sensitive Cardiac troponin T (hs-cTnT). The investigators will also measure arterial bloodgas, oxygen uptake, carbon dioxide consumption, ventilation, blood pressure, ECG, heart rate and ask for dyspnea-score.

Enrollment: 20 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD
• GOLD 2-4
• BODE-index ≥ 2
• Referred by physician to a CPET

Exclusion criteria

• Other serious pulmonary diseases (e.g. cancer, sarcoidosis, restrictive pulmonary diseases)
• Chronic heart disease with unstable angina or myocardial infarction ≤ 3 months prior to inclusion
• Percutaneous coronary intervention (PCI)
• Hypertension that is not controlled

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Treadmill exercise test

Experimental group

Description:

Patients are subjected to an incremental Cardiopulmonary Exercise Test to exhaustion

Treatment:

Device: Treadmill exercise test