Truth or Dare; Artificial Blastocoel Collapse Using Laser Before Blastocyst's Vitrification Versus Non-laser Usage

Benha University

Status: Terminated

Conditions: Blastocyst Disintegration

Treatments: Device: laser assisted collapse

Study type: Interventional

Funder types: Other

Identifiers

NCT04124809

Hawaa-7

Details and patient eligibility

About

: This prospective randomized observational study aimed to compare behavior of artificially collapsed blastocysts to blastocysts that were vitrified without artificial collapse.

Full description

One arm study of 60 patients with sibling blastocysts divided into 2 groups: Study group (artificially laser-collapsed blastocysts; n=71) & control group (blastocysts were vitrified without laser collapse; n=66) then reexpansion speed and survival rate was assessed immediately & at 140 min after thawing and compared between two groups.

Enrollment: 10 patients

Sex: Female

Ages: 20 to 37 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age limit 20-37 At least 6 good quality blastocysts per case. expansion rate 3-4

Exclusion criteria

• bad quality blastocysts expansion rate less than 3

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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10 participants in 2 patient groups

Study group (artificially laser-collapsed blastocysts)

Experimental group

Description:

laser was used as an intervention before blastocyst vitrification to assist rapid blastocyst collapse with vitrification

Treatment:

Device: laser assisted collapse

& control group (blastocysts were vitrified, no laser collapse

No Intervention group

Description:

blastocyst were vitrified without laser assisted collapse