Tumor Associated Macrophage in Advanced Non-small Cell Lung Cancer

Chang Gung Medical Foundation

Status: Completed

Conditions: Advanced Nonsmall Cell Lung Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01551251

100-0522B

Details and patient eligibility

About

The purpose of this study is to investigate the effects of tumor associated macrophage (TAM) in advanced non-small cell lung cancer (NSCLC) patients on the treatment response and outcome of these subjects. Pathologic specimens from tissue bank will be stained by immunostaining methods with CD68 antibody. The clinical treatment response and outcomes will be analyzed between high or low TAM.

Enrollment: 107 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• advanced NSCLC,
• more than 20 years old,
• measurable tumor,
• response and outcome recorded after the first line treatment.

Exclusion criteria

• Early stage NSCLC,
• less than 20 years,
• pregnancy,
• unmeasurable NSCLC.

Trial design

107 participants in 2 patient groups

Advanced NSCLC with high TAM

Description:

All patients with advanced non-small cell lung cancer who had been treated at the Linkou Branch of Chang Gung Memorial Hospital were included. Tumor specimens with high TAM were included as one cohort group.

Advanced NSCLC with low TAM

Description:

All patients with advanced non-small cell lung cancer who had been treated at the Linkou Branch of Chang Gung Memorial Hospital were included. Tumor specimens with low TAM were included as one cohort group.