Tumor-Derived Extracellular Vesicles for Noninvasive Molecular Classification of Kidney Cancer

Mayo Clinic

Status: Not yet enrolling

Conditions: Kidney Cancer; Clear-cell Renal Cell Carcinoma; Renal Cell Carcinoma; Chromophobe Renal Cell Carcinoma; Papillary Renal Cell Carcinoma

Treatments: Procedure: Blood sample collection; Other: Proteomic profiling of urinary EVs

Study type: Observational

Funder types: Other

Identifiers

NCT07243067

25-003121

HT9425-25-1-0607 (Other Grant/Funding Number)

Details and patient eligibility

About

This is a correlative (lab-based) study aiming to identify protein markers in urine extracellular vesicles (EVs) that can be used to develop non-invasive molecular tests for patients with renal cell carcinoma (RCC). Aim 1 will use urine collected previously in biorepository. Aim 2 will prospectively collect blood specimens pre and post nephrectomy.

Enrollment: 300 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Urine sample in existing biorepository
• High-risk renal cell carcinoma (RCC) per American Urological Association (AUA) guidelines
• Scheduled to undergo nephrectomy

Exclusion criteria

• Does not meet inclusion criteria

Trial design

300 participants in 4 patient groups

Clear-cell RCC

Description:

Participants with clear-cell RCC

Treatment:

Other: Proteomic profiling of urinary EVs

Procedure: Blood sample collection

Papillary RCC

Description:

Participants with papillary RCC

Treatment:

Other: Proteomic profiling of urinary EVs

Procedure: Blood sample collection

Chromophobe RCC

Description:

Participants with chromophobe RCC

Treatment:

Other: Proteomic profiling of urinary EVs

Procedure: Blood sample collection

Benign Renal Tumor

Description:

Participants with benign renal tumors

Treatment:

Other: Proteomic profiling of urinary EVs