Tumor Immune Mechanism of Axillary Lymph Node Metastasis in Early Luminal Type A Breast Cancer

Peking University

Status: Unknown

Conditions: Lymph Node Metastases; Luminal A; Immune Microenvironment

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04322331

IO Panel

Details and patient eligibility

About

Luminal type A breast cancer is a type with good clinical prognosis, and the proportion of lymph node metastasis is low, but a small number of patients have more lymph node metastasis when the primary tumor is very small, and the survival is poor, suggesting that this part of Luminal A breast cancer has the different expression of some genes from that of general Luminal A breast cancer, which affects tumor invasion and participates in the occurrence of tumor metastasis. But the mechanism is not clear, especially in the current tumor microenvironment and immune related mechanisms.We want to investigated the relationship of the transcriptional tumor immune microenvironment with early lymph node metastasis among Luminal A type breast cancer.

Enrollment: 120 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• invasive breast cancer with Luminal A type;T1 with positive lymph node or T2/T3 with negative lymph node

Exclusion criteria

• Missing specimen

Trial design

120 participants in 2 patient groups

T1N+

Description:

T1 tumor with positive lymph node,N1/N2/N3

Treatment:

Other: no intervention

T2/T3N0

Description:

T2/T3 tumor with negative lymph node

Treatment:

Other: no intervention