Tumor Microenvironment in Patients With Localized Osteosarcoma Treated With Mifamurtide: a Translational Study (Micros)

Istituto Ortopedico Rizzoli

Status: Completed

Conditions: Localized Osteosarcoma

Study type: Observational

Funder types: Other

Identifiers

NCT03737435

Micros

Details and patient eligibility

About

International, multicenter retrospecitve biological study

Full description

International, multicenter retrospecitve biological study that will analyze the tumor micro environment in biological archival samples of patients, who were treated with chemotherapy +/- mifamurtide according the protocols for primary localized osteosarcoma (ISG-OS2 and GEIS-33)

Enrollment: 80 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with primary localized osteosarcoma who received chemotherapy +/- mifamurtide according to ISG-OS2/GEIS-33 trials,
2. Paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the biological analysis
3. Written informed consent prior to any study-specific analysis and/or data collection

Exclusion criteria

1) Patients with diagnosis different from osteosarcoma

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Trial design