Tumor Necrosis Factor-alpha and Interleukin-18 Levels in Children With Gingivitis and Type 1 Diabetes Mellitus

Aydin Adnan Menderes University

Status: Completed

Conditions: Periodontal Diseases

Treatments: Diagnostic Test: ELISA

Study type: Observational

Funder types: Other

Identifiers

NCT03910205

2019-062

Details and patient eligibility

About

This study aimed to evaluate the levels of interleukin 18 and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) of children with type 1 diabetes mellitus and gingivitis.

Full description

Eighty eight children (44 with type 1 diabetes mellitus and 44 healty; age range 7-14 years) will be recruited for the study. The children will be classified into four subgroups based on their periodontal status; 1) Children with gingivitis and diabetes mellitus (MG, n=22); 2) Children with type 1 diabetes mellitus with healthy periodontium (MH, n=22); 3)Healthy children with gingivitis (HG, n=22); 4) Healthy children with healthy periodontium (HH, n=22). Probing pocket depth (PPD), gingival index (GI) and plaque index (PI) will be recorded. Interleukin-18 and TNF-α will be analyzed in GCF and saliva samples by ELISA.

Enrollment: 88 patients

Sex: All

Ages: 7 to 14 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children diagnosed as type 1 diabetes mellitus
• Age between 7 and 14 years

Exclusion criteria

• Having another systemic problem except type 1 diabetes mellitus
• Children carrying orthodontic appliances

Trial design

88 participants in 4 patient groups

Type 1 diabetes with gingivitis

Description:

Children with type 1 diabetes mellitus and gingivitis

Treatment:

Diagnostic Test: ELISA

Type 1 diabetes with healthy gingiva

Description:

Children with type 1 diabetes mellitus and healthy gingiva

Treatment:

Diagnostic Test: ELISA

Healthy patients with gingivitis

Description:

Systemically healthy patients with gingivitis

Treatment:

Diagnostic Test: ELISA

Healthy patients with healthy gingiva

Description:

Systemically healthy patients with healthy gingiva

Treatment:

Diagnostic Test: ELISA