Tumor-specific T Cells in Lung Cancer

University Hospital Heidelberg

Status: Active, not recruiting

Conditions: Non-small Cell Lung Cancer

Treatments: Device: Illinois bone marrow aspiration neddle; Procedure: Bone marrow aspiration from the iliac crest

Study type: Interventional

Funder types: Other

Identifiers

NCT02515760

S-515/2013

Details and patient eligibility

About

Non-small cell lung cancer is characterized by aggressive growth and treatment resistance. New approaches include immunotherapeutic strategies but spontaneous immune responses against tumor antigens remain unclear. The aim of this study is to characterize localization and frequencies of spontaneously induced memory T cells specific for a panel of tumor-associated antigens in peripheral blood and bone marrow of non-small cell lung cancer patients.

Enrollment: 120 patients

Sex: All

Ages: 18 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with histology proven non-small cell lung cancer or a lesion suspicious of non-small cell lung cancer (lung cancer group)
• Healthy donors (control group)
• written informed consent

Exclusion criteria

• Autoimmune disease
• Patients receiving immunomodulatory drugs, e.g. tacrolimus
• Prior malignancy
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Lung cancer group

Experimental group

Description:

Bone marrow puncture in patients with non-small cell lung cancer

Treatment:

Procedure: Bone marrow aspiration from the iliac crest

Device: Illinois bone marrow aspiration neddle

Control group (healthy donors)

Experimental group

Description:

Bone marrow puncture in healthy donors

Treatment:

Procedure: Bone marrow aspiration from the iliac crest

Device: Illinois bone marrow aspiration neddle