Turmeric Effect on Reduction of Serum Prolactin and Related Hormonal Change and Adenoma Size in Prolactinoma Patients

Mashhad University of Medical Sciences

Status and phase: Unknown; Phase 1

Conditions: Hyperprolactinoma

Treatments: Drug: Curcumin

Study type: Interventional

Funder types: Other

Identifiers

NCT01344291

Turmeric-01

Details and patient eligibility

About

Prolactinoma is the most prevalent anterior hypophysis tumor. The principal treatment for this disorder is Dopamine agonist drugs including bromocriptin and Cabergoline. However, 50% of Bromocriptin treated and 17% of Cabergoline treated patients are resistant to these drugs. Curcumin is the main derivative of turmeric ,an old spice which is used frequently in Indian and Iranian cuisine. It has been proved that curcumin can reduce mammotrope cells proliferation and also intracellular hormone production. The purpose of this study is to evaluate the effect of turmeric on prolactinoma patients.

Enrollment: 30 estimated patients

Sex: Female

Ages: 20 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hyperprolactinemia
• microprolactinoma

Exclusion criteria

• pregnancy
• macroadenoma
• neurologic signs due to tumor

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)