Two Approaches in Enhancing the Efficacy of Inferior Alveolar Nerve Block During Treatment of Mandibular First Permanent Molars With Symptomatic Irreversible Pulpitis

Minia University

Status: Enrolling

Conditions: Pain, Procedural

Treatments: Procedure: Cryotherapy; Procedure: Buccal local anesthetic infiltration using articaine 4% 1:100000 epinephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT05427903

602

Details and patient eligibility

About

The study is designed as a randomized parallel controlled trial with three groups. Participants aged above 18 years with the first permanent molars with symptomatic signs of irreversible pulpitis will be randomly assigned into 3 groups. The first group (experimental group) will be injected with 4% articaine 1:100.000 epinephrine (inferior alveolar nerve block) will be anesthetized using 4% articaine 1:100.000 plus cryotherapy application, and the second group (experimental group) will be anaesthetised with IANB plus buccal infiltration. For the third group (control group), the mandibular molars will be anaesthetized using epinephrine using the inferior alveolar nerve block.

Enrollment: 180 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients aged above 18 years
• Presence of at least one mandibular first permanent molar, with signs and symptoms of irreversible pulpititis

Exclusion criteria

• Participants with a history of taking medications that could interfere with the action of the anaesthetic solutions
• Presence of paresthesia
• Presence of psychological problems
• Taking analgesics or other medications that would alter the inflammatory response of the pulp or provide analgesia 12 h pre-operatively

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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180 participants in 3 patient groups

Cryotherapy

Experimental group

Treatment:

Procedure: Buccal local anesthetic infiltration using articaine 4% 1:100000 epinephrine

IANB plus buccal infiltration local anesthesia

Experimental group

Treatment:

Procedure: Cryotherapy

IANB

Active Comparator group

Treatment:

Procedure: Cryotherapy

Procedure: Buccal local anesthetic infiltration using articaine 4% 1:100000 epinephrine