Two Cut-Off Values of Plethysmographic Variability Index to Guide Intraoperative Fluid Therapy on Serum Lactate in Patients Undergoing Excision of Supra-Tentorial Brain Tumors

Cairo University (CU)

Status

Completed

Conditions

Fluid Therapy

Excision

Intraoperative

Serum Lactate

Plethysmographic Variability Index

Cut-Off Value

Supra-Tentorial Brain Tumors

Treatments

Other: Fluid Therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT07174128

MD--452-2023

Details and patient eligibility

About

This study aimed to compare two cut-off values of plethysmographic variability index (PVI) -guided fluid therapy in patients undergoing supra-tentorial mass excision regarding immediate postoperative serum lactate.

Full description

Fluid therapy in patients undergoing craniotomy is very critical; hypovolemia might decrease cerebral perfusion, while fluid overinfusion might cause brain swelling that impairs surgical removal of lesions.

The plethysmographic variability index (PVI) is one of the dynamic indices of fluid responsiveness, a simple, automatic, non-invasive, and continuous method based on calculating changes in the perfusion index (PI).

Enrollment

32 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age above 18 years old.
Both sexes.
Patients scheduled for supra-tentorial brain tumor excision.

Exclusion criteria

Arrhythmias.
Pulmonary hypertension.
Impaired cardiac contractility.
Impaired liver or kidney function.
Low lung compliance.
Body mass index above 40.
Intra-operative hemodynamic instability on vasopressors or inotropes.
Peripheral arterial occlusive diseases.
Hand injuries or burns that preclude the application of the Masimo device probe.