Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis (2d-BR)

University of Exeter

Status: Withdrawn

Conditions: Healthy

Treatments: Behavioral: Bed rest; Behavioral: Habitual activity

Study type: Interventional

Funder types: Other

Identifiers

NCT03877822

190206/B/05

Details and patient eligibility

About

The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

Full description

To study the mechanisms underlying inactivity-induced muscle atrophy, the impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Aged 18-40

Exclusion criteria

• Smoker
• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
• Any diagnosed cardiovascular disease (e.g. deep vein thrombosis or hypertension)
• Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism).
• A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
• Any known disorders in muscle metabolism
• Regular use of nutritional supplements (i.e. ingestion more than twice per week during the last month)
• Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
• Allergy to lidocaine
• Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Habitual activity and 2 days bed rest

Experimental group

Description:

Participants will undergo 2 days of habitual activity and 2 days bed rest

Treatment:

Behavioral: Habitual activity

Behavioral: Bed rest