Two-dimensional Shear-Wave Elastography Evaluate Esophageal Varices Bleeding Risk of Liver Cirrhosis

Sichuan University

Status: Unknown

Conditions: Esophageal Varices; Liver Stiffness; Liver Cirrhosis

Treatments: Diagnostic Test: Gastroscopy

Study type: Observational

Funder types: Other

Identifiers

NCT03989973

2D-SWE evaluate varices

Details and patient eligibility

About

The purpose of this retrospective study was to investigate the diagnostic performance of 2D-SWE for predicting the presence of esophageal varices and high-risk varices in patients with liver cirrhosis.

Full description

Variceal bleeding is a fatal complication in patients with liver cirrhosis. A screening esophagogastroduodenoscopy (EGD) is recommended in all patients with cirrhosis to identify those patients at risk of variceal bleeding. However, this technique is invasive, uncomfortable and costly. Moreover, with the development of noninvasive technology for early diagnosis of liver cirrhosis, half of these patients will not develop varices within 10 years and therefore will undergo unnecessary EGD screening. Thus, the need for noninvasive screening methods for varices in patients with cirrhosis is urgent.

2D-SWE is a promising new type of shear wave-based ultrasound technique for measuring LS. The shear waves are generated directly within the tissue by acoustic radiation force impulse, allowing the measurement of stiffness in patients with ascites. In addition, the LS values can be obtained on the basis of anatomic information to avoid major vessels and control major measurement bias. 2D-SWE has been reported to have high reliability and reproducibility in assessing liver stiffness. Several studies compared TE with 2D-SWE in predicting fibrosis stages and portal hypertension, which suggested that 2D-SWE has a higher technical success rate and a better diagnostic value for portal hypertension than TE.The purpose of this retrospective study was to investigate the diagnostic performance of 2D-SWE for predicting the presence of esophageal varices and high-risk varices in patients with liver cirrhosis.

Enrollment: 500 estimated patients

Sex: All

Ages: 16 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cirrhosis were diagnosed by liver biopsy, CT and ultrasound before enrolled
• Age was 16-80

Exclusion criteria

• With bleeding history
• With EVL history, BRTO or TIPS history
• With NSBB history
• With ascites
• With splenectomy or splenic embolism, history
• With liver cancer

Trial design

500 participants in 1 patient group

Cirrhosis patients

Description:

Patients were diagnosed by liver biopsy, CT or ultrasound

Treatment:

Diagnostic Test: Gastroscopy