Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients (MOSAR-04)

University Hospitals (UH)

Status: Completed

Conditions: MRSA Infection

Treatments: Behavioral: Hand hygiene promotion; Other: Rapid molecular MRSA test

Study type: Interventional

Funder types: Other

Identifiers

NCT00685867

LSHP-CT-037940

Details and patient eligibility

About

The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level. A total of ten adult surgical departments with at least 3 surgical subspecialties each will participate in the study. Sites of the study are located in 9 countries (UK, France, Spain, Germany, Switzerland, Italy, Serbia, Greece and Israel).

The primary objective is to determine the effect of an early MRSA detection & decolonization & isolation strategy compared to an enhanced standard control strategy on healthcare-associated MRSA isolation rates among surgical patients at risk of MRSA carriage, who are hospitalized for at least 24 hours.

Enrollment: 126,750 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Surgical patients with LOS>24h

Exclusion criteria

• Surgical patients with LOS<24h

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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126,750 participants in 2 patient groups

1

Experimental group

Description:

Rapid detection

Treatment:

Other: Rapid molecular MRSA test

2

Other group

Description:

Enhanced infection control

Treatment:

Behavioral: Hand hygiene promotion