Type 1 Diabetes Autonomic and Vascular Function

The University of Texas System (UT)

Status

Invitation-only

Conditions

Type 1 Diabetes

Type 1 Diabetes (Juvenile Onset)

Diabetes, Autoimmune

Study type

Observational

Funder types

Other

Identifiers

NCT06786546

STUDY00004548

Details and patient eligibility

About

The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answer are:

Patients with type 1 diabetes exhibit attenuated vascular function during steady-state exercise
Patients with type 1 diabetes have altered autonomic function at rest and during exercise pressor reflex
Patients with type 1 diabetes have attenuated muscle sympathetic activity

Full description

Elevated blood glucose levels in individuals with type 1 diabetes can result in both microvascular and macrovascular complications. Research conducted by Song et al. revealed that children with type 1 diabetes exhibit abnormal cerebral perfusion. Additionally, autonomic mechanisms are affected in type 1 diabetes, as indicated in an animal study which demonstrated that the exercise pressor reflex is exaggerated in both male and female rats during the early stages of the disease. However, whether this also occurs in human patients with type 1 diabetes remains unknown.

Therefore, in this study we are interested in studying the autonomic control of exercise and vascular function in T1DM humans.

Enrollment

72 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria