Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity (HIT)

The University of Texas System (UT)

Status: Completed

Conditions: Insulin Sensitivity/Resistance

Treatments: Other: 8 weeks of combined exercise intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT02745613

755513-1

Details and patient eligibility

About

This study investigates weather a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity in the hispanic population

Full description

A family history of T2D (FH+) is a risk factor for developing insulin resistance (which precedes T2D) and T2D (Ryder et al., 2003). Exercise training on the other hand has been shown to improve insulin sensitivity and is highly effective to prevent/manage T2D. However it is not known if early signs of insulin resistance appear before being clinically diagnosed and if the benefits of exercise which prevent/cure T2D, are limited to the offspring of Hispanic T2D parents. Therefore, the proposed study will determine 1) if normoglycemic (normal blood glucose) offspring of T2D parents are insulin resistant, using the gold standard method to measure insulin sensitivity and metabolic flexibility (ability to switch between carbohydrate and fat oxidation) 2) if 8 weeks of exercise training improves insulin sensitivity and metabolic flexibility to the same extent in FH+ compared to normoglycemic offspring of parents without any history of T2D (FH-) and 3) if 8 weeks of exercise training will change the blood, lipid and molecular profiles relevant to insulin sensitivity to same extent in FH+ compared to offspring of parents without family history of T2D (FH-).

Enrollment: 24 estimated patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 ≤ Age ≤ 40 years
• 18 ≤ BMI ≤ 30 kg/m2
• Both parents are Mexican/Mexican-American)
• Sedentary lifestyle
• Less than 60 minutes/wk. of structured exercise
• Physical activity level ≤ 1.4

Exclusion criteria

• Evidence of significant cardiovascular disease or diabetes
• A fasting blood glucose ≥100 mg/dL
• Screening blood pressure >140/90
• Hyperlipidemia
• Use of drugs affecting energy metabolism or body weight
• Excess alcohol, drug abuse, and smoking
• Eating disorder or eating attitudes interfering with study
• Unwillingness to be abide by randomization

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups

Family history of T2D

Experimental group

Description:

The participants will undergo 8 weeks of combined exercise

Treatment:

Other: 8 weeks of combined exercise intervention

No Family history of T2D

Experimental group

Description:

The participants will undergo 8 weeks of combined exercise

Treatment:

Other: 8 weeks of combined exercise intervention