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Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity (HIT)

The University of Texas System (UT) logo

The University of Texas System (UT)

Status

Completed

Conditions

Insulin Sensitivity/Resistance

Treatments

Other: 8 weeks of combined exercise intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT02745613
755513-1

Details and patient eligibility

About

This study investigates weather a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity in the hispanic population

Full description

A family history of T2D (FH+) is a risk factor for developing insulin resistance (which precedes T2D) and T2D (Ryder et al., 2003). Exercise training on the other hand has been shown to improve insulin sensitivity and is highly effective to prevent/manage T2D. However it is not known if early signs of insulin resistance appear before being clinically diagnosed and if the benefits of exercise which prevent/cure T2D, are limited to the offspring of Hispanic T2D parents. Therefore, the proposed study will determine 1) if normoglycemic (normal blood glucose) offspring of T2D parents are insulin resistant, using the gold standard method to measure insulin sensitivity and metabolic flexibility (ability to switch between carbohydrate and fat oxidation) 2) if 8 weeks of exercise training improves insulin sensitivity and metabolic flexibility to the same extent in FH+ compared to normoglycemic offspring of parents without any history of T2D (FH-) and 3) if 8 weeks of exercise training will change the blood, lipid and molecular profiles relevant to insulin sensitivity to same extent in FH+ compared to offspring of parents without family history of T2D (FH-).

Enrollment

24 estimated patients

Sex

Male

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 18 ≤ Age ≤ 40 years
  • 18 ≤ BMI ≤ 30 kg/m2
  • Both parents are Mexican/Mexican-American)
  • Sedentary lifestyle
  • Less than 60 minutes/wk. of structured exercise
  • Physical activity level ≤ 1.4

Exclusion criteria

  • Evidence of significant cardiovascular disease or diabetes
  • A fasting blood glucose ≥100 mg/dL
  • Screening blood pressure >140/90
  • Hyperlipidemia
  • Use of drugs affecting energy metabolism or body weight
  • Excess alcohol, drug abuse, and smoking
  • Eating disorder or eating attitudes interfering with study
  • Unwillingness to be abide by randomization

Trial design

Primary purpose

Health Services Research

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

24 participants in 2 patient groups

Family history of T2D
Experimental group
Description:
The participants will undergo 8 weeks of combined exercise
Treatment:
Other: 8 weeks of combined exercise intervention
No Family history of T2D
Experimental group
Description:
The participants will undergo 8 weeks of combined exercise
Treatment:
Other: 8 weeks of combined exercise intervention

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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