Type I Collagen Fragments in the GCF and Saliva During OTM

Alexandria University

Status: Unknown

Conditions: Collagen Degeneration

Treatments: Other: Biological measuring of collagen fragments biomarker during orthodontic tooth movement

Study type: Interventional

Funder types: Other

Identifiers

NCT05020431

Collagen Fragments ICTP, CTX.

Details and patient eligibility

About

Investigate the levels of type I Collagen fragments ICTP and CTX in GCF and saliva during initial leveling and alignment of the teeth in a sample of adolescents undergoing orthodontic treatment.

Full description

Type I Collagen fragments ICTP (cross-linked carboxyterminal telopeptide of type 1 collagen) and CTX (C-terminal cross-linked telopeptide of type I collagen) are specific bone resorption biomarkers released in the circulation after osteoclastic bone resorption and collagen degradation and were found to be released in gingival crevicular fluid (GCF) and saliva during metabolic bone diseases and active periodontitis. So the aim of the study is to investigate the levels of ICTP and CTX in GCF and saliva during initial leveling and alignment of the teeth in a sample of adolescents undergoing orthodontic treatment.

Enrollment: 14 estimated patients

Sex: All

Ages: 13 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The age ranges from 13-18 years old.
• Good oral hygiene.
• Clinical gingival health on the intact periodontium.
• Permanent dentition.
• Moderate crowding.
• Non-extraction treatment plan. If extraction of teeth is required, the treatment plan should allow for postponing extraction after sample collection.

Exclusion criteria

• Systemic diseases associated with loss of periodontal supporting tissues.
• Metabolic bone diseases and systemic medications affecting bone metabolism.
• Craniofacial anomalies such as cleft lip and/or palate.
• Xerostomia.
• Tobacco-related habits such as smoking, tobacco chewing, etc.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 1 patient group

One arm

Experimental group

Description:

One arm nonrandomized clinical trial

Treatment:

Other: Biological measuring of collagen fragments biomarker during orthodontic tooth movement