U/S-guided Continuous Quadratus Lumborum Block III in Percutaneous Nephrolithotomy

Nazmy Edward Seif

Status: Completed

Conditions: Renal Stone; Surgery; Analgesia

Treatments: Procedure: Single dose Quadratum Lumborum Block III; Procedure: Intra-venous Morphine; Procedure: Continous Quadratum Lumborum Block III

Study type: Interventional

Funder types: Other

Identifiers

NCT04800302

USGCQLBIIIPCNL

Details and patient eligibility

About

Percutaneous nephrolithotomy (PCNL) is considered to be the first choice and a more conservative procedure than open stone surgery. Not only postoperative pain related to dilatation of the renal capsule and parenchymal tract, but also patient's discomfort & nephrostomy tube-related stress are reported to delay recovery time and increase the complication rates. This study is designed to provide postoperative analgesia by using ultrasound-guided continuous Quadratus Lumborum Block (QLB) III in patients undergoing PCNL and to assess pain scores & side effects with less opioids consumption.

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II.
• Scheduled for percutaneous nephrolithotomy (PCNL).

Exclusion criteria

• Patient refusal.
• Coagulation disorders.
• Skin lesions or infection at site of needle insertion.
• Known allergy to local anesthetics or opioids.
• Patients suffering from neurological or mental disease.
• Procedure turned into open stone surgery.
• Failure of identification by U/S.
• Urinary tract malignancies.
• Opioid consumption 48 hours before the operation.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 3 patient groups

Continuous QLB group

Experimental group

Description:

U/S-guided continous QLB III

Treatment:

Procedure: Continous Quadratum Lumborum Block III

Procedure: Intra-venous Morphine

Procedure: Single dose Quadratum Lumborum Block III

Single dose QLB group

Active Comparator group

Description:

U/S-guided single dose QLB III

Treatment:

Procedure: Intra-venous Morphine

Procedure: Single dose Quadratum Lumborum Block III

Morphine group

Active Comparator group

Description:

IV Morphine

Treatment:

Procedure: Intra-venous Morphine