U01-Biomarkers for Noninvasive and Early Detection of Pancreatic Cancer

Hoag Health Network

Status: Enrolling

Conditions: Pancreatic Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT03886571

119-17-CA

Details and patient eligibility

About

This is an observational, biospecimen collection protocol to develop a bank of pancreatic cancer tissue and normal tissue.

Full description

This is an observational, biospecimen collection protocol to develop a bank of pancreatic cancer tissue, normal tissue. Biospecimens collected through this protocol will be shared with collaborators in the Pancreatic Cancer Detection Consortium to support projects funded through an NIH U01 grant. Participants will be enrolled when they present for clinically indicated surgical procedures for their possible tumor or pancreas resection or cyst resection, or at a clinically indicated follow-up appointment after their procedure.

This protocol supports this effort by providing investigators with access to a wide variety of pancreatic tissues and biospecimens for translational studies in pancreatic cancer. This protocol covers the collection of clinical data and biospecimens (blood; malignant, benign, or precancerous pancreatic tumor; and adjacent normal tissues) from patients with, or suspected to have, pancreatic cancer. Additionally, saliva and cyst fluid, may be collected in the future from patients with pancreatic cysts. These will be shared with the Pancreatic Cancer Detection Consortium for further analysis.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Males or Females ≥ 18 years of age who have been diagnosed with Pancreatic Cancer (PDAC), Pancreatic Neoplasms (PNs - IPMMs, PanINs and MCNs), pancreatitis and diabetes or no disease/healthy.
• Individuals undergoing or have previously undergone a diagnostic procedure (i.e. EUS or ERCP) evaluation or surgery.
• Willingness and ability to donate biospecimens for the purpose of research.
• Subjects must have had diagnostic procedure or surgery after September 1, 2017.

Exclusion criteria

• Individuals under 18 years of age.
• Inability to donate biospecimens.
• Females pregnant or lactating.