UEMR Versus HSP in the Treatment of Pedunculated Colorectal Polyps Less Than 10mm in Size

Fudan University

Status: Not yet enrolling

Conditions: Pedunculated Colorectal Polyp

Treatments: Procedure: underwater endoscopic mucosal resection; Procedure: Hot snare polypectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT06996522

2025K132

Details and patient eligibility

About

A prospective, single-center, open-label, randomized controlled study to compare the effectiveness and safety of underwater endoscopic mucosal resection (UEMR) and hot snare polypectomy (HSP) in treating Pedunculated colorectal polyps less than 10mm in size.

Full description

1. Patients are undergone screening, surveillance, or therapeutic colonoscopy at the Endoscopy department of Gastrointestinal endoscopy center of Huadong hospital affiliated to Fudan University.
2. Randomize patients with pedunculated colorectal polyps less than 10mm in size into 2 interventional groups based on Random function of Statistical Package for the Social Sciences (SPSS) 20.0, including (1) Group 1: Underwater endoscopic mucosal resection (UEMR) and (2) Group 2: Hot snare polypectomy (HSP).
3. Collecting variables which consist of primary and secodary outcomes.

Enrollment: 338 estimated patients

Sex: All

Ages: 35 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged between 35 and 80 years
• Pedunculated colorectal polyps less than 10mm in size in screening, surveillance or therapeutic colonoscopy
• 0-Isp or 0-Ip according to Paris classification
• Patients must sign an informed consent form prior to registration in study

Exclusion criteria

• Unsuitable for removal by UEMR or HSP
• Suspected malignancy
• History of inflammatory bowel disease or colorectal resection
• Familial adenomatous polyposis or Lynch syndrome
• Patients taking anticoagulant and antiplatelet agents before the examination
• Inadequate bowel preparation, defined as a Boston Bowel Preparation Scale score < 6
• ASA >=3
• Pregnancy or breastfeeding
• Severe comorbid disease involving the heart, lungs, liver, or kidneys.
• Concurrent serious conditions, including other active malignancies or severe infectious diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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338 participants in 2 patient groups

UEMR in treating Pedunculated colorectal polyps less than 10mm in size

Experimental group

Description:

The UEMR procedure included the following: (1) Water infusion to distend the intestinal lumen; (2) entrapment of the mucosal protrusion with a snare; and (3) resection using electrocautery

Treatment:

Procedure: underwater endoscopic mucosal resection

HSP in treating Pedunculated colorectal polyps less than 10mm in size

Active Comparator group

Description:

The HSP procedure included the following: (1) entrapment and resection of the polyp with a snare with electrocautery.

Treatment:

Procedure: Hot snare polypectomy