Ulmus Macrocarpa Hance Extract and Lipid Profile

Sang Yeoup Lee

Status: Completed

Conditions: Dyslipidemias

Treatments: Dietary Supplement: UMH extract; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03773315

02-2018-029

Details and patient eligibility

About

The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the Ulmus Macrocarpa Hance extract on lipid profile in adults with dyslipidemia for 12 weeks.

Full description

Previous another our study have indicated that Ulmus Macrocarpa Hance extract (UMH) may have the ability to decrease blood cholesterol. Therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the UMH on lipid profile in adults with dyslipidemia; the safety of the compound are also evaluate. The Investigators examine total cholesterol, HDL-cholesterol, triglyceridemia, LDL-cholesterol, and other biochemical parameters at baseline, as well as after 6 and 12 weeks of intervention. Eighty adults were administered either 500 mg of UMH or a placebo each day for 12 weeks;

Enrollment: 80 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• LDL cholesterol ranging from 130 to 190 mg/dL

Exclusion criteria

• Abnormal liver or renal function (i.e., serum aminotransferase activity > 80 IU/L and serum creatinine concentrations > 1.2 mg/dL)
• Diabetes (diagnosed clinically or fasting glucose level > 126 mg/dL)
• History of ischemic heart disease or cerebrovascular disease
• Uncontrolled hypertension
• History of serious cardiac disease such as angina or myocardial infarction
• History of gastrectomy
• History of medication for psychiatric disease
• Administration of oriental medicine including herbs within the past 4 weeks

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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80 participants in 2 patient groups, including a placebo group

UMH group

Experimental group

Description:

This group takes UMH extract for 12 weeks

Treatment:

Dietary Supplement: UMH extract

Placebo group

Placebo Comparator group

Description:

This group takes placebo for 12 weeks

Treatment:

Dietary Supplement: Placebo