Ultra-early Chest CT for SAP Prediction (SENTRY)

Capital Medical University

Status: Enrolling

Conditions: Stroke-associated Pneumonia; Acute Ischaemic Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT07321275

SENTRY

Details and patient eligibility

About

Stroke-associated pneumonia (SAP) is a common and serious complication after acute ischaemic stroke (AIS). Existing scores rely mainly on clinical variables, and the added prognostic value of inflammatory markers and early chest CT findings remains uncertain. We developed and externally validated an early multimodal model combining clinical severity, inflammation, and chest CT abnormalities, and explored risk-stratified associations between prophylactic antibiotics and SAP.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients aged ≥18 years;
2. Admitted to a participating stroke centre with neuroimaging-confirmed acute ischaemic stroke ;
3. Had chest CT performed within 24 hours of stroke onset.

Exclusion criteria

1. Pneumonia;
2. Chest CT images unavailable or incomplete for assessment;
3. Insufficient clinical documentation to ascertain stroke-associated pneumonia occurrence within 7 days after stroke onset

Trial design

1,000 participants in 2 patient groups

Development (Derivation) cohort

External validation cohort