Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease

Oregon Health & Science University (OHSU)

Status: Unknown

Conditions: REM Sleep Behavior Disorder; Parkinson Disease

Treatments: Other: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT03288909

eIRB#5611

Details and patient eligibility

About

This is a prospective observational study investigating the utility of 7 Tesla MRI to quantify nigrosome1 signal in a cohort of individuals with recent onset Parkinson's disease and in at-risk cohorts at a premotor state of Parkinson's disease.

Enrollment: 18 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Idiopathic Parkinson's disease within 1 year of motor symptom onset. Idiopathic REM sleep behavior disorder without signs/symptoms of Parkinson's disease.

Age-matched controls.

Exclusion criteria

• Atypical Parkinsonism
• Contraindications for MRI

Trial design

18 participants in 3 patient groups

Early onset Parkinson's disease

Description:

Idiopathic Parkinson's disease within 1 year of symptom onset

Treatment:

Other: MRI

Idiopathic REM Sleep Behavior Disorder

Description:

Idiopathic REM Sleep Behavior Disorder

Treatment:

Other: MRI

Age-matched healthy controls

Description:

Age-matched healthy controls

Treatment:

Other: MRI