Ultra-low-dose Chest CT for HHT

Mayo Clinic

Status: Completed

Conditions: Hereditary Hemorrhagic Telangiectasia

Treatments: Diagnostic Test: Ultra-low dose chest CT

Study type: Observational

Funder types: Other

Identifiers

NCT04874558

21-000324

Details and patient eligibility

About

This study aims to develop a novel ultra-low dose chest CT technology for use in Hereditary Hemorrhagic Teleangiectasia (HHT) patients and to determine the lowest possible radiation dose that is achievable without sacrificing the diagnostic quality.

Enrollment: 3 patients

Sex: All

Ages: 1 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ages 1 to 17 years
• Diagnosed with positive HHT causing mutations or based on Curacao criteria

Exclusion criteria

• Acute respiratory distress
• Unstable cardiovascular status
• Pneumothorax, hemoptysis
• Pulmonary edema
• Pulmonary emboli
• Fractured ribs or other chest trauma
• Recent bronchoscopy
• Lung transplantation

Trial design

3 participants in 1 patient group

Low-dose contrast-enhanced chest CT exam

Description:

Subjects will undergo a low-dose contrast-enhanced chest CT exam with coverage from the neck base through the lungs to the upper abdomen on a third-generation dual-source CT scanner as part of their routine clinical visit based on current guidelines.

Treatment:

Diagnostic Test: Ultra-low dose chest CT