Ultra-Low Dose Computed Tomography For Diagnosis And Follow-Up Of Patients With Diffuse Parenchymal Lung Disease (DPLD)

Sheba Medical Center

Status: Unknown

Conditions: Diffuse Parenchymal Lung Disease

Study type: Observational

Funder types: Other

Identifiers

NCT04392726

SHEBA-20-7020-20-SMC-LL-CTIL

Details and patient eligibility

About

The primary intention of this study is to determine the diagnostic performance of ultra-low-dose CT (ULDCT) in diagnosis and follow-up of diffuse parenchymal lung disease (DPLD). We hypothesize that inspiratory and expiratory chest ULDCT has comparable diagnostic yield to standard dose chest High-resolution computed tomography (HRCT) and utility for follow-up of patients with known DPLD. We will study this hypothesis through the following aims:

1. Determine whether inspiratory and expiratory ULDCT are comparable to HRCT in identifying mosaic attenuation due to air-trapping.
2. Determine whether ULDCT is as good as HRCT for follow-up of patients with established DPLD to identify disease progression.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. suspected or known DPLD
2. referred to DPLD observation

Exclusion criteria

1. other lung related diseases

Trial design

30 participants in 2 patient groups

patients with suspected DPLD

patients with known DPLD