Long Pressure Autoregulation Index (Long PAx)

Papa Giovanni XXIII Hospital

Status: Completed

Conditions: Traumatic Brain Injury

Study type: Observational

Funder types: Other

Identifiers

NCT05043545

PapaGiovanni H

Details and patient eligibility

About

The pressure reactivity index (PRx) has emerged as a surrogate method for the continuous bedside estimation of global cerebral autoregulation and a significant predictor of unfavorable outcomes. However, calculations require continuous, high-resolution monitoring and are currently limited to specialized ICUs with dedicated software. To overcome this problem, new indices calculated using one-minute average data, instead of 10-second average data as performed by the PRx, have been proposed.

The study aims to test new physiological indices appropriately modified to adapt to the scarcity of output data generated by standard hospital systems (frequency ~0.0033 Hz, approximately a 5-minute period) and to evaluate their association with outcome measures.

Full description

Data preparation and index calculations were performed using an in-house algorithm.

Data extracted and processed with the algorithm:

Ultra-low pressure reactivity index (UL-PRx), Intracranial pressure (ICP), Cerebral perfusion pressure (CPP), Arterial blood pressure (ABP), heart rate (HR), respiratory rate (RR), temperature, end-tidal CO2 (EtCO2), saturation (SpO2).

Enrollment: 263 patients

Sex: All

Ages: 1+ month old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a clinical diagnosis of acute neurological injury requiring intracranial pressure (ICP) monitoring.
• Availability of continuous intensive care monitoring of physiological data.

Exclusion criteria

Patients with less than 8 hours of physiological data monitoring.