Ultra Processed Foods Consumption and Impact in Rheumatic Diseases. (NUTRIRIC)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Osteoarthritis; Spondyloarthritis; Rheumatoid Arthritis

Treatments: Other: Evaluation of disease activity (DAS-28, ASDAS, EVA, number of swollen joints, number of painful joint, nocturnal pain, morning stiffness); Other: Dietary Questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT06776965

2024-A02327-40 (Other Identifier)

69HCL24_0947

Details and patient eligibility

About

Ultra-processed foods (UPF) represent one of the mainstays of today's diet. They are defined by the NOVA classification system. It was demonstrated that UPF consumption was associated with activity of inflammatory bowel diseases with underlying mechanisms not fully identified yet. It is suspected that UPF constituents could modify the gut microbiota, increase intestinal barrier permeability and directly engage immune surveillance systems, effects that could individually or synergistically increase the risk of immunomediated diseases. As some pathophysiological mechanisms are shared among IBD and rheumatic diseases, we have wondered if UPF consumption could be associated with increased risk of rheumatic disease and/or with their activity.

Our primary aim will be to study the pattern of UPF consumption in patients with rheumatic diseases. Our secondary objectives will be to study the activity of diseases according to UPF consumption.

Enrollment: 240 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• chronic rheumatic disease (Rheumatoid arthritis, spondyloarthritis, osteoarthritis)
• ability to perform questionnaires

Exclusion criteria

• Judicial protection measure
• Refusal to participate in the study
• Suffering from 2 rheumatic disease simultaneously

Trial design

240 participants in 4 patient groups

Rheumatoid Arthritis

Description:

Patients in the first group will correspond to those with rheumatoid arthritis according to ACR criteria of RA

Treatment:

Other: Dietary Questionnaire

Other: Evaluation of disease activity (DAS-28, ASDAS, EVA, number of swollen joints, number of painful joint, nocturnal pain, morning stiffness)

Spondyloarthritis

Description:

Patients in the second group will correspond to those with spondyloarthritis according ASDAS criteria

Treatment:

Other: Dietary Questionnaire

Other: Evaluation of disease activity (DAS-28, ASDAS, EVA, number of swollen joints, number of painful joint, nocturnal pain, morning stiffness)

Osteoarthritis

Description:

Patients in the third group will correspond to those with spondyloarthritis according ACR criteria

Treatment:

Other: Dietary Questionnaire

Other: Evaluation of disease activity (DAS-28, ASDAS, EVA, number of swollen joints, number of painful joint, nocturnal pain, morning stiffness)

Controls

Description:

Patients without rheumatic disease

Treatment:

Other: Dietary Questionnaire

Other: Evaluation of disease activity (DAS-28, ASDAS, EVA, number of swollen joints, number of painful joint, nocturnal pain, morning stiffness)