Ultra-Widefield Fluorescein Angiography-Based Targeted Retinal Photocoagulation Versus Conventional Panretinal Photocoagulation in the Preservation of Visual Function and Regression of Proliferative Diabetic Retinopathy

Hayatabad Medical Complex

Status: Completed

Conditions: Proliferative Diabetic Retinopathy - High Risk

Treatments: Procedure: Green laser

Study type: Interventional

Funder types: Other

Identifiers

NCT06653361

306/DME/KMC

Details and patient eligibility

About

Proliferative diabetic retinopathy is a vision-threatening disease that can lead to irreversible visual loss. The treatment options for proliferative diabetic retinopathy are anti-VEGF injection and retinal photocoagulation. The study aims to compare ultra-widefield fluorescein angiography-based targeted retinal photocoagulation and panretinal photocoagulation in the treatment of proliferative diabetic retinopathy.

Enrollment: 120 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• proliferative diabetic retinopathy (PDR) with neovascularization on the disc or elsewhere in the retina

Exclusion criteria

• Participants with a history of previous history of:
• retinal photocoagulation
• vitreoretinal surgery
• tractional retinal detachment
• epiretinal membrane
• vitreomacular traction
• glaucoma
• uveitis
• media opacities like cataract, corneal opacity, vitreous hemorrhage
• anti-VEGF injections in last 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

TRP

Experimental group

Description:

Targeted Retinal Photocoagulation

Treatment:

Procedure: Green laser

PRP

Active Comparator group

Description:

Panretinal Photocoagulation

Treatment:

Procedure: Green laser