Ultrafiltration on Coagulation Function in Cardiac Surgery

Konkuk University Medical Center

Status: Enrolling

Conditions: Cardiac Valve Disease

Treatments: Procedure: Ultrafiltration

Study type: Interventional

Funder types: Other

Identifiers

NCT04031144

KUMC 2019-05-008

Details and patient eligibility

About

To determine the effect of modified ultrafiltration, which is usually employed for reducing free water at the end of cardiopulmonary bypass (CPB), on coagulation profile in patients undergoing cardiac surgery

Enrollment: 28 estimated patients

Sex: All

Ages: 19 months to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB)
• maximal clot formation (MCF) in ROTEM-EXTEM is reduced

Exclusion criteria

• MCF > 50.5 mm before applying ultrafiltration
• transfusion of packed RBC> 3 units during CPB
• total ultrafiltration volume < 250 ml
• hyperfibrinolysis (lysis% > 10%) before applying ultrafiltration

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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28 participants in 1 patient group

Ultrafiltration

Experimental group

Description:

Ultrafiltration is applied at the end of cardiopulmonary bypass. Maximal clot formation (MCF) of ROTEM-EXTEM tracing is reduced before applying the ultrafiltration.

Treatment:

Procedure: Ultrafiltration