Ultrafine Particles and Fetal Contamination (FOETOPUF)

University Hospital of Bordeaux

Status: Completed

Conditions: Pollution; Exposure; Lung; Premature

Treatments: Procedure: Pulmonary Tissue Collection

Study type: Observational

Funder types: Other

Identifiers

NCT04068389

CHUBX 2008/04

Details and patient eligibility

About

The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.

Full description

Epidemiological studies have demonstrated the harmful effects of particulate air pollution on the progress of pregnancy and postnatal health.

Experimental studies have suggested the transplacental passage of asbestos fibers, but despite the strong growth in the use and production of fine and ultrafine particles, no study has examined the permeability of the placenta to these compounds or the exposures fetuses that may result.

The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.

Enrollment: 62 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• All women volunteers for whom a medical termination of pregnancy is proposed for a fetus older than 22 weeks (weight over 500g).

Exclusion criteria

• Refusal of participation of the patient.
• Fetus with malformation syndrome affecting pulmonary perfusion.