Ultrasonic Explorations of Cerebral Tissue Motions - Influence of Aging (COSTUM)

Regional University Hospital Center (CHRU)

Status

Completed

Conditions

Cerebral Pulsatility

Aging

Treatments

Device: Fast Cerebral Pulsatility Imaging

Study type

Interventional

Funder types

Other

Identifiers

NCT01737606

PHAO 2012 - FP / COSTUM

Details and patient eligibility

About

The new technical of ultrasonic exploration of this project purpose to validate the measurement of cerebral pulsatility by a new way called "Fast Cerebral Pulsatility Imaging" (FCPI).This will somehow determine the natural history of cerebral pulsatility during development adult to old age

Full description

Main objective

Phase 1:

-Study the in-vivo development of ultrasonic method in terms of quality of the acquisitions and intra-operator reproducibility.

Study the ease of positioning in relation to MRI and fusion of MRI and FCPI data via the neuro-navigation system

Phase 2:

-Study the variability of cerebral pulsatility of measured by "Fast Cerebral Pulsatility Imaging" or FCPI with age.

Secondary objectives

Compare the results of displacements cartography's and vascular cartography obtained by MRI (especially by Arteriel Spin Labelling = ASL)
Compare results of FCPI with results of cognitive tests of aging separating fluid functions (prefrontal) and functions called crystallized; and study the residual effect of age on cognitive tasks and speed of cognitive processing after taking into account the effect of the cerebral pulsatility
Compare results of FCPI with electrophysiological measures (PE EEG) describing the attentional control
Perform an exploratory analysis to highlight the propagating part of the brain displacement maps

Enrollment

53 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patient at least 18 years old
Informed consent form signed
Person affiliated to a medical insurance
Male or female
No smoking the day of the inclusion
Right handed: Edinburgh test ≥0.8 (subjects of phase 2)
MMS score ≥ 27 and 5 words score = 10 (subjects of phase 2)
Socio-educational level greater than or equal to 8 years of school (subjects of phase 2)

Exclusion criteria

Pregnant women, lactating women or women without reliable contraception
Contraindications to IRM for patients with: ocular metallic foreign object; any electronic medical device implanted by irremovable way (pacemakers, neuro-stimulator, cochlear implants ...); metallic heart valve, old heart valves are specially an absolute contraindication because of risk of dysfunction; vascular clips implanted formerly on brain aneurysm
Acute medico-surgical condition dating from less than 3 months
Neurological and neuro-surgical pathology such as: toxic, infectious or inflammatory encephalopathy, epilepsy, intracranial arteriovenous malformation known, intracranial tumor or hydrocephalus known, operated or no, history of ischemic or hemorrhagic stroke, transient or not
Treatments or pathology that could influence the results of the research: heart failure (dyspnea with stage III or IV NYHA) or non-sinus cardiac rhythm, use of central analgesics or psychotropic drugs
Psychiatrics disorders of axe 1 of DSM IV, based on MINI (subjects of phase 2)
Major subject with a legal protection measure
Subject to exclusion period of any other biomedical research