Ultrasonication-mediated Microbubbles Dressing for Hand Arthritis

National Taiwan University

Status: Enrolling

Conditions: Hand Arthritis

Treatments: Procedure: ultrasonication using pure gel; Procedure: ultrasonication-mediated microbubbles dressing

Study type: Interventional

Funder types: Other

Identifiers

NCT06913088

TCVGH-1123802B

Details and patient eligibility

About

The goal of this clinical trial is to learn if ultrasonication-mediated microbubbles dressing works to treat hand arthritis in adults. It will also learn about the safety of ultrasonication-mediated microbubbles dressing. The main questions it aims to answer are:

Does ultrasonication-mediated microbubbles dressing increase the therapeutic efficacy of piroxicam gel for hand arthritis?

Researchers will compare "ultrasonication-mediated microbubbles dressing + piroxicam gel " to "ultrasonication + piroxicam gel" and "piroxicam gel alone" to see if ultrasonication-mediated microbubbles dressing works to treat hand arthritis.

Participants will:

Take "ultrasonication-mediated microbubbles dressing (day 1,3,5) + piroxicam gel (day 2,4,6,7) ", "ultrasonication (day 1,3,5) + piroxicam gel (day 2.4.6.7)", and "piroxicam gel alone (day 1-7)" for 1 week.

Visit the clinic on day 1 and day 8 for checkups and tests Keep a diary of their symptoms

Enrollment: 60 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of hand arthritis
• Have at least three symptomatic joints over wrist, metacarpophalangeal joints, and interphalangeal joints

Exclusion criteria

• Infectious arthritis
• Acute gout

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 3 patient groups

MBUS group

Experimental group

Description:

ultrasonication-mediated microbubbles dressing (day 1,3,5) + piroxicam gel (day 2,4,6,7)

Treatment:

Procedure: ultrasonication-mediated microbubbles dressing

US group

Sham Comparator group

Description:

ultrasonication using pure gel (day 1,3,5) + piroxicam gel (day 2,4,6,7)

Treatment:

Procedure: ultrasonication using pure gel

Control group

No Intervention group

Description:

piroxicam gel alone (day 1-7)