Ultrasonographic Assessment of the Effect of CPB Acute Lung Injury (CBP)

Cairo University (CU)

Status: Unknown

Conditions: Lung Ultrasound

Treatments: Procedure: lung recruitment

Study type: Interventional

Funder types: Other

Identifiers

NCT03619525

lung ultrasound after CPB

Details and patient eligibility

About

The study is designed to use the lung ultrasound to assess the effect of intermittent lung recruitment during cardiopulmonary bypass in cardiac surgeries on extra vascular lung water.

Full description

Significant respiratory dysfunction is a common problem after cardiac surgery, with an incidence of about 25%. the formation of atelectasis appears to be the primary factor responsible for increased intrapulmonary shunt after cardiac surgery with CPB. The investigators will use the lung ultrasound to evaluate the effects of intermittent recruitment of the lungs during CPB on extra vascular lung water (EVLW).

Objectives :

To evaluate the effect of intermittent lung recruitment during CPB in cardiac surgery on:

Lung ultrasound score (LUS),Oxygenation at different times postoperatively,Time for extubation and length of ICU stay

sixty patients aged from 18-60 years old, scheduled for elective cardiac surgery with CPB will be included in the study. Patients will be randomly allocated into one of two groups: Group A (n=30): will receive intermittent lung recruitment during CPB.Group B (n=30): control group.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult patients aged (18-60 years),
• elective valvular cardiac surgery with cardiopulmonary bypass (CPB).

Exclusion criteria

• • Emergency surgeries.

  • coronary artery bypass graft surgery
  • patients requiring re-exploration in the immediate postoperative period (within 2hours)
  • left Ventricular ejection fraction less than 40%
  • patients with preoperative congestive heart failure, cardiogenic shock , preoperative pulmonary edema
  • pre-existing severe chronic pulmonary dysfunction (defined as pulmonary disease requiring home oxygen therapy or causing shortness of breath after 1 to 2 flights of stairs)
  • Morbid obesity
  • Renally impaired patients with creatinine more than 2 mg/dl

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

recruitment group

Active Comparator group

Description:

will receive intermittent lung recruitment during CPB

Treatment:

Procedure: lung recruitment

control group

No Intervention group

Description:

will recieve no intervention