Ultrasonographic of Diaphragmatic Function in Obstructive Sleep Apnea

Mansoura University

Status: Completed

Conditions: OSA

Study type: Observational

Funder types: Other

Identifiers

NCT07370376

MS.23.03.2352

Details and patient eligibility

About

Obstructive sleep apnea (OSA) is associated with altered respiratory mechanics, including diaphragmatic function. Ultrasonography provides a non-invasive tool to assess diaphragmatic structure and performance, which may correlate with OSA severity.

Full description

Obstructive sleep apnea (OSA) is associated with altered respiratory mechanics, including diaphragmatic function. Ultrasonography provides a non-invasive tool to assess diaphragmatic structure and performance, which may correlate with OSA severity. The aim of the study is to evaluate diaphragmatic function in OSA patients using ultrasonography and to investigate its relationship with OSA severity and sleep-related parameters.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients visiting the Sleep Disordered Breathing (SDB) Unit at the Chest Medicine Department and diagnosed with obstructive sleep apnea (OSA) were included if they met the following criteria:
• Age 18-65 years.
• Willingness to participate in the study.

Exclusion criteria

• Patients were excluded if they had any of the following conditions:
• Refusal to participate in the study
• Age <18 or >65 years
• Systemic organ failure, including heart failure, stroke, renal failure, or liver failure; Uncontrolled diabetes mellitus
• Diagnosed obesity hypoventilation syndrome (OHS) or other sleep disorders apart from OSA
• Chronic respiratory diseases such as COPD, bronchial asthma, or restrictive lung disease
• OSA patients already receiving therapy (CPAP, oral appliances, or upper airway surgery)
• Neuromuscular disorders or other conditions affecting diaphragmatic function (malnutrition, chest trauma, or immobility)
• Use of steroids or uncontrolled autoimmune diseases.

Trial design

60 participants in 2 patient groups

newly diagnosed OSA patients (AHI ≥5)

Description:

30 newly diagnosed OSA patients (AHI ≥5). All participants underwent pulmonary function testing, and completed Epworth Sleepiness Scale (ESS), Berlin, and STOP-Bang questionnaires. Overnight, attended polysomnography (PSG) was performed following AASM guidelines. Diaphragm ultrasonography measured excursion, thickness at end-expiration and inspiration, and diaphragm thickening fraction (DTF).

non-OSA controls (AHI <5)

Description:

All participants underwent pulmonary function testing, and completed Epworth Sleepiness Scale (ESS), Berlin, and STOP-Bang questionnaires. Overnight, attended polysomnography (PSG) was performed following AASM guidelines. Diaphragm ultrasonography measured excursion, thickness at end-expiration and inspiration, and diaphragm thickening fraction (DTF).