Ultrasonography Guided Pleural Biopsy Versus Computed Tomography Guided Pleural Biopsy

Eskisehir Osmangazi University

Status: Completed

Conditions: Pleural Diseases

Treatments: Procedure: Ultrasonography guided cutting pleural needle biopsy; Procedure: CT-Guided pleural needle biopsy with Abrams' needle

Study type: Interventional

Funder types: Other

Identifiers

NCT01196585

082010/2

Details and patient eligibility

About

This study aims to compare the diagnostic efficiency and reliability of Abrams' needle pleural biopsy under computerized tomography guidance with that of cutting-needle pleural biopsy under ultrasonography guidance in patients with pleural effusion.

Full description

Background. In cases with pleural effusion, tissue samples can be obtained through Abrams' needle pleural biopsy, thoracoscopy, or cutting-needle pleural biopsy under the guidance of computerized tomography or ultrasonography for histopathological analysis. This study aims to compare the diagnostic efficiency and reliability of Abrams' needle pleural biopsy under computerized tomography guidance with that of cutting-needle pleural biopsy under ultrasonography guidance in patients with pleural effusion.

Methods. Patients with exudative pleural effusion, who could not be diagnosed by cytological analysis, will be included in the study. All patients were randomized following the thoracic computerized tomography with contrast enhancement. Patients either underwent Abrams' needle pleural biopsy under computerized tomography guidance or the cutting-needle pleural biopsy under ultrasonography. The two groups will be compared in terms of diagnostic efficiency and in terms of complications associated with the methods used.

Enrollment: 120 estimated patients

Sex: All

Ages: 20 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with exudative pleural effusion who require invasive procedure for diagnosis

Exclusion criteria

• Patients without pleural effusion

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

120 participants in 2 patient groups

Patients under CT- guided pleural biopsy

Experimental group

Description:

Arm A: Patients who go under CT-guided pleural needle biopsy for pleural diseases

Treatment:

Procedure: CT-Guided pleural needle biopsy with Abrams' needle

Patients under ultrasonography guided needle biopsy

Experimental group

Description:

Arm B: Patients who go under ultrasonography guided cutting needle pleural biopsy for pleural diseases

Treatment:

Procedure: Ultrasonography guided cutting pleural needle biopsy