Ultrasound Acute Chest Syndrome Sickle Cell Disease (POCUS)

Indiana University

Status: Enrolling

Conditions: Sickle Cell Disease; Acute Chest Syndrome

Treatments: Device: Point of Care Ultrasound

Study type: Interventional

Funder types: Other

Identifiers

NCT06880679

PHO-IIR-POCUS

Details and patient eligibility

About

Feasibility and reliability of ultrasound in the inpatient hematology setting.

Full description

Acute chest syndrome (ACS) is a complication of sickle cell disease where individuals have symptoms of fever, low oxygen levels or difficulty breathing in the setting of a new lung finding on chest x-ray. Chest x-ray is a useful tool to identify it but has some side effects. The investigators think ultrasound will be an equally feasible, reliable tool and minimize some of the side effects associated with chest x-ray. Ultrasound is a non-invasive was to obtain an image that does not require radiation.

Enrollment: 30 estimated patients

Sex: All

Ages: Under 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age: 0-25 years old
2. Diagnosis: Patients with a documented diagnosis of sickle cell disease (any genotype)
3. Disposition: Hospitalized for a SCD-related complication (e.g. VOC)

Exclusion criteria

1. Patient is considered hemodynamically unstable to undergo consent and study procedures
2. Already has diagnosis of ACS prior to admission to inpatient unit
3. POCUS operator not available

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Ultrasound

Experimental group

Description:

Ultrasound days 1, 3, and 5 of hospitalization

Treatment:

Device: Point of Care Ultrasound