Ultrasound and Photoacoustic Imaging for Cervical Cancer

The Washington University

Status: Terminated

Conditions: Cancer of the Cervix; Cervical Cancer

Treatments: Device: Transvaginal probe using photoacoustic and ultrasound imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT03318107

201710024

Details and patient eligibility

About

The investigators have developed co-registered transvaginal photoacoustic and ultrasound (US) imaging techniques that allow them to visualize ovarian tumor structure and functional changes simultaneously, which may potentially reveal early tumor angiogenesis development or residual tumors after systemic treatment that is not available by US alone. The ability to detect early angiogenesis changes, as well as tumor morphology changes using a non-invasive imaging modality will greatly enhance the care for patients. The investigators plan to explore these techniques in monitoring cervical cancer treatment response and conduct pilot feasibility studies.

Enrollment: 2 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Diagnosis of cervical cancer of any stage that will be treated with radiation therapy and concurrent chemotherapy.
• At least 18 years of age.
• Not pregnant and/or breastfeeding.
• Able to understand and willing to sign an IRB-approved written informed consent document.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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2 participants in 1 patient group

Transvaginal probe (Photoacoustic + ultrasound imaging)

Experimental group

Description:

* A transvaginal imaging probe using ultrasound and photoacoustic imaging will be inserted into the vagina and will use different frequencies of lights to create images * This will occur before the first standard of care treatment, mid-treatment, end of treatment, and approximately 3 months after the end of treatment for a total of 4 imaging time points

Treatment:

Device: Transvaginal probe using photoacoustic and ultrasound imaging