Ultrasound Evaluations of Diaphragm and Intercostal Muscle to Predict the Failure of High-Flow Nasal Cannula Therapy

Fudan University

Status: Enrolling

Conditions: Diaphragm and Intercostal Muscle; High-flow Nasal Cannula; Ultrasound Evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT06375538

B2022-527

Details and patient eligibility

About

The study aims to predict the failure of High-flow Nasal Cannula oxygenation therapy by ultrasound evaluation of diaphragm and intercostal muscle contraction during the first 24 hours.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• more than 18 years old
• needing High-flow Nasal Cannula oxygenation therapy

Exclusion criteria

• received mechanical ventilation, including invasive or noninvasive ventilation within one month prior to enrollment
• history of neuromuscular disorders (e.g., myasthenia gravis, Guillain-Barre syndrome);
• immediate endotracheal intubation is required (life-threatening hypoxemia)
• extensive damage to the thoracic skin (e.g., burns) unable to undergo ultrasonography
• pregnancy
• attending physician deemed it inappropriate to participate in the trial.