Ultrasound Guided Aspiration of Hydrosalpingeal Fluid and IVF-ET Outcomes

Cairo University (CU)

Status and phase: Completed; Phase 2

Conditions: Infertility

Treatments: Procedure: ultrasound guided aspiration of hydrosalpingeal fluid

Study type: Interventional

Funder types: Other

Identifiers

NCT01040351

hydrosalpinx1

Details and patient eligibility

About

The aim of this study is to determine whether the ultrasound guided aspiration of hydrosalpingeal fluid at the time of oocyte retrieval can improve the outcomes of IVF-ET .

Full description

A Cochrane review of prospective randomized trials of laparoscopic salpingectomy confirmed the beneficial effect of laparoscopic salpingectomy on IVF ET outcomes in patients with hydrosalpinges. Surgery is not usually safe especially in patients with extensive adhesions, morbid obesity and previous multiple laparotomies. Other less invasive options for patients with hydrosalpinges as ultrasound guided aspiration of hydrosalpingeal fluid, antibiotics and hysteroscopic occlusion of fallopian tube were studied in order to find an alternative to salpingectomy. Although these methods are simple and getting popular,current data are inadequate to recommend these treatment options instead of salpingectomy. The aim of this study is to determine whether the ultrasound guided aspiration of hydrosalpingeal fluid at the time of oocyte retrieval can improve the outcomes of IVF-ET .

Enrollment: 110 patients

Sex: Female

Ages: 18 to 37 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with unilateral or bilateral hydrosalpinges visible by ultrasound
• Age between 18 - 37 years
• Period of infertility > 1 year
• Body mass index between 19-29
• Normal basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin concentrations
• Normal recent semen analysis (according to World Health Organization criteria)

Exclusion criteria

• Uterine fibroid requiring surgical removal
• Endometriosis
• Male factor of infertility requiring ICSI
• Previous IVF cycles
• History of recurrent miscarriage
• Endocrinologic disorders
• Presence of systemic disease contraindicating pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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110 participants in 2 patient groups

1: Hydrosalpinx needle aspiration

Experimental group

Description:

After the retrieval of oocytes an aspiration needle is inserted into the hydrosalpinx under ultrasonographic guidance and suction is applied to aspirate the hydrosalpingeal fluid completely .

Treatment:

Procedure: ultrasound guided aspiration of hydrosalpingeal fluid

2. no aspiration

No Intervention group

Description:

IVF-ET is done without prior aspiration of hydrosalpingeal fluid