Ultrasound-guided Continuous Low Serratus Anterior Plane Block in Hepatocellular Carcinoma Surgery (RCT)

Liu Di

Status: Enrolling

Conditions: Postoperative Analgesia; Liver Neoplasms; Serratus Anterior Plane Block

Treatments: Procedure: Ultrasound-guided single serratus anterior plane block; Procedure: Ultrasound-guided continuous low serratus anterior plane block

Study type: Interventional

Funder types: Other

Identifiers

NCT05531864

JF20PJ288

Details and patient eligibility

About

To investigate the clinical application of ultrasound-guided continuous low serratus anterior plane block in open surgery for hepatocellular carcinoma.

Full description

METHODS: Patients with hepatocellular carcinoma who attended our hospital from January 2021 to April 2023 were divided into CS group and N group according to the random number table method; CS group underwent ultrasound-guided continuous low anterior serratus plane block and N group underwent ultrasound-guided single anterior serratus plane block combined with rectus abdominis sheath block; the operation time, anesthesia time, incision length, sensory block time and sensory block maintenance time were counted and recorded. Pain score (NRS) was used to detect analgesia; alanine aminotransferase (ALT), liver function aspartate aminotransferase (AST), and prothrombin time (The time of thrombin, NRS) were measured by fluorescent quantitative PCR. （The time of thrombin (APTT), total bilirubin (TBIL) levels and adverse reactions.

Enrollment: 160 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 18-60 years;
2. ASAI-II;
3. BMI: 18-29 kg/m2

Exclusion criteria

1. Combined cardiac, cerebral, hepatic, and renal failure;
2. Comorbid psychiatric and neuromuscular disorders;
3. A history of allergy to anesthetic drugs;
4. Participation in other recent clinical or drug trials.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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160 participants in 2 patient groups

Continuous serratus anterior plane block

Experimental group

Description:

Ultrasound-guided continuous serratus anterior plane block.

Treatment:

Procedure: Ultrasound-guided continuous low serratus anterior plane block

Single serratus anterior plane block combined with rectus sheath nerve block

Active Comparator group

Description:

Ultrasound-guided single serratus anterior plane block combined with rectus sheath nerve block.

Treatment:

Procedure: Ultrasound-guided single serratus anterior plane block