Ultrasound Guided Core Biopsy vs Fine Needle Aspiration for Evaluation of Axillary Lymphadenopathy

University of Pittsburgh

Status: Completed

Conditions: Focus: Breast Cancer With Axillary Node Metastasis

Treatments: Other: Titanium marker; Procedure: Axillary surgery; Procedure: Fine needle aspiration and core biopsy of lymph node

Study type: Interventional

Funder types: Other

Identifiers

NCT01920139

PRO07100450

Details and patient eligibility

About

The study was performed to determine if either ultrasound guided core biopsy or fine needle aspiration of an axillary lymph node has superior sensitivity in detecting metastatic carcinoma from the ipsilateral breast.

Full description

Women with suspected or recently diagnosed breast cancer and ipsilateral abnormal appearing axillary lymph nodes underwent fine needle aspiration immediately followed by core biopsy of the same lymph node.Cytology results from the fine needle aspiration (FNA)and histology from the core biopsy were compared to surgical pathology from axillary node excision to determine if either method of percutaneous node sampling was more sensitive in detecting metastasis. Pain during each procedure was also compared.

Enrollment: 105 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women with breast cancer and abnormal ipsilateral axillary nodes visible on sonography.

Exclusion criteria

• Inability to understand consent form.
• Emotionally unprepared to discuss possibility of axillary metastasis
• Node not amenable to core biopsy

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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105 participants in 1 patient group

Breast cancer and Axillary Adenopathy

Other group

Description:

Women with breast cancer with abnormal appearing ipsilateral axillary nodes undergoing fine needle aspiration and core biopsy of a lymph node.

Treatment:

Procedure: Axillary surgery

Other: Titanium marker

Procedure: Fine needle aspiration and core biopsy of lymph node