Ultrasound-guided Erector Spinae Plane Block Versus Paravertebral Block for Perioperative Analgesia in Patients Undergoing Open Splenectomy

Ain Shams University

Status and phase: Completed; Phase 3

Conditions: Analgesia

Treatments: Drug: conventional analgesia; Procedure: ultrasound guided paravertebral block; Procedure: ultrasound guided erector spinae plane block

Study type: Interventional

Funder types: Other

Identifiers

NCT05448469

R 97/2022

Details and patient eligibility

About

There are very few randomized controlled trials in open splenectomy surgery, which compare paravertebral block with ESP block. The purpose of this randomized controlled trial is to compare the efficacy of ultrasound-guided paravertebral block with ESP block for perioperative analgesia in open splenectomy .

Enrollment: 99 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who will be scheduled for indicated open splenectomy surgery in the supine position via left subcostal ,midline or letf subcostal with midline extention incisions
• physical status American Society of Anesthesiologists (ASA) II or III.

Exclusion criteria

• Patients who refuse to participate
• patients with body mass index (BMI) >35 kg/m2
• infection at the site of injection
• coagulopathy, severe thrombocytopenia <50×103
• spine deformity
• history of opioid dependence
• polytrauma patients with dorsal spine fracture
• urgent abdominal exploration for splenectomy in heamodynamically unstable patients
• history of allergy to opioids or local anesthetics
• history of allergy to opioids, or local anaesthetics.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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99 participants in 3 patient groups

general anesthesia+ bilateral US guided erector spinae plane block

Active Comparator group

Description:

General anesthesia plus ultrasound guided erector spinae plane block with 20 ml bupivacaine 0.2% at T9

Treatment:

Procedure: ultrasound guided erector spinae plane block

general anesthesia+ bilateral US guided paravertebral block

Active Comparator group

Description:

General anesthesia plus bilateral US guided paravertebral block with 7 ml bupivacaine 0.2% at T8 and T10

Treatment:

Procedure: ultrasound guided paravertebral block

general anesthesia

Active Comparator group

Description:

general anesthesia plus conventional analgesia

Treatment:

Drug: conventional analgesia