Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery

Tanta University

Status: Enrolling

Conditions: Umbilical Hernia; Rectus Abdominis Plane Block; Neuroendocrine Stress Response; External Oblique; Ultrasound

Treatments: Other: General anesthesia; Other: External oblique and rectus abdominis plane (EXORA) block

Study type: Interventional

Funder types: Other

Identifiers

NCT07324863

36265MD474/10/25

Details and patient eligibility

About

This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.

Full description

Umbilical hernias of the abdomen are defined as a non-inguinal, non-hiatal defect in the fascia of the abdominal wall. Surgical stress response refers to the physiologic response to surgery and the hormonal and metabolic changes that follow it.

Fascial plane blocks are gaining attention for perioperative analgesia due to their efficacy and safety profiles. The external oblique and rectus abdominis plane (EXORA) block is an emerging technique that provides a sensory block to the anterolateral abdominal wall, potentially filling gaps left by other commonly used blocks, such as the quadratus lumborum (QLB) or erector spinae plane (ESP) blocks.

Enrollment: 100 estimated patients

Sex: All

Ages: 21 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged from 21 to 65 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) Physical status I and Ⅱ.
• Schedule for elective umbilical hernia surgery under general anesthesia.

Exclusion criteria

• ASA Ⅲ or Ⅳ.
• Patients with metabolic abnormalities, e.g., diabetes mellitus.
• Patients receiving corticosteroids.
• History of allergies to local anesthetics.
• Bleeding or coagulation disorders.
• Anatomical abnormalities.
• Psychiatric and neurological disorders.
• Complicated hernial defect (obstructed).
• Patient refusal.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

Group I

Active Comparator group

Description:

Patients will receive general anesthesia only.

Treatment:

Other: General anesthesia

Group Ⅱ

Experimental group

Description:

Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.

Treatment:

Other: External oblique and rectus abdominis plane (EXORA) block