Ultrasound-guided PRP Versus Steroid Injections in Management of Carpal Tunnel Syndrome

Tanta University

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Carpal Tunnel Syndrome

Treatments: Drug: Saline; Drug: Triamcinolone Acetonide; Drug: platlet rich plasma (PRP)

Study type: Interventional

Funder types: Other

Identifiers

NCT04434105

001

Details and patient eligibility

About

Patients will be randomly divided into 3 equal groups: Group I received ultrasound guided injection of 2 mL PRP into the affected carpal tunnel. Group II received ultrasound guided injection of 2 mL steroids (40 mg triamcinolone acetonide). Group III received ultrasound guided injection of 2 mL saline as placebo control.

Full description

Patients will be randomly divided into 3 equal groups: Group I received ultrasound guided injection of 2 mL PRP into the affected carpal tunnel. Group II received ultrasound guided injection of 2 mL steroids (40 mg triamcinolone acetonide). Group III received ultrasound guided injection of 2 mL saline as placebo control.

Each group will be injected twice with 2 weeks intervals. All procedures were done after informed consent. Evaluation of the patients at baseline, 3 and 6 months after last injection was done clinically by measuring visual analogue scale (VAS), electrophysiologically (by measuring motor and sensory nerve conduction studies of median nerve using a standardized technique) and ultrasonographic study by measuring cross sectional area (CSA) of median nerve at the level of pisiform.

Enrollment: 90 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• mild or moderate idiopathic CTS (diagnosed clinically, ultrasonography & electrophysiologically and classified according to the American Association of neuromuscular diagnostic medicine monograph).

Exclusion criteria

• Patients with severe or secondary type of CTS

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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90 participants in 3 patient groups, including a placebo group

PRP group

Experimental group

Description:

patients received ultrasound-guided injection of 2 mL PRP into the affected carpal tunnel.patients will be injected twice with 2 weeks intervals

Treatment:

Drug: platlet rich plasma (PRP)

Steroid group

Active Comparator group

Description:

patients received ultrasound-guided injection of 2 mL steroids (40 mg triamcinolone acetonide). into the affected carpal tunnel. patients will be injected twice with 2 weeks intervals

Treatment:

Drug: Triamcinolone Acetonide

Control group

Placebo Comparator group

Description:

patients received ultrasound-guided injection of 2 mL saline patients will be injected twice with 2 weeks intervals

Treatment:

Drug: Saline