Ultrasound Guided Serratus Anterior Versus Erector Spinae Block in Pain Alleviation in Acute Herpes Zoster

Minia University

Status: Not yet enrolling

Conditions: Acute Herpes Zoster Neuropathy

Treatments: Procedure: Serratus anterior block; Procedure: ultrasound guided erector spine block

Study type: Interventional

Funder types: Other

Identifiers

NCT06476080

1084

Details and patient eligibility

About

Acute herpes zoster pain is very severe . Conventional analgesics may be of no value. Regional blocks may play a role

Enrollment: 120 estimated patients

Sex: All

Ages: 30 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult population between 30 and 75 years old.
• Unilateral painful thoracic herpetic eruption of less than one week duration.
• VAS more than or equal 4, persistent pain in spite of proper antiviral and analgesic therapy, (800 mg oral acyclovir, 5 times per day, for one week), pregabalin 300 mg per day, acetaminophen 1000 mg per day, topical calamine lotion).

Exclusion criteria

• Diabetic patients.
• Painful herpetic eruptive vesicles more than one week.
• Abdominal herpetic eruptions.
• Non-compliant on anti-viral (bulbar palsy for example).
• Co-malignancy or radiotherapy.
• Steroid therapy > 5 mg prednisolone or its equivalent.
• Infections or hematoma at site of injection.
• Coagulopathy (chronic kidney or liver disease, clopidogrel use).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

120 participants in 3 patient groups

Control group

No Intervention group

Description:

800 mg acyclovir, 5 times / day, orally administered, for one week, acetaminophen 1000 mg per day, topical calamine lotion)

Erector spinae group

Active Comparator group

Description:

800 mg acyclovir, 5 times / day, orally administered, for one week, acetaminophen 1000 mg per day, topical calamine lotion)+ 25 ml bupivacaine 0.25% plus 8 mg dexamethasone

Treatment:

Procedure: ultrasound guided erector spine block

Serratus anterior group

Active Comparator group

Description:

800 mg acyclovir, 5 times / day, orally administered, for one week, acetaminophen 1000 mg per day, topical calamine lotion)+ 25 ml bupivacaine 0.25% plus 8 mg dexamethasone

Treatment:

Procedure: Serratus anterior block