Ultrasound-Guided Subtransverse Interligamentary Block Versus Thoracic Paravertebral Block for Postoperative Analgesia in Patients Undergoing Open Nephrectomy

Tanta University

Status: Enrolling

Conditions: Subtransverse Interligamentary Block; Postoperative Analgesia; Thoracic Paravertebral Block; Open Nephrectomy

Treatments: Other: Thoracic paravertebral block; Other: Subtransverse process interligamentary

Study type: Interventional

Funder types: Other

Identifiers

NCT07138794

36264PR1283/7/25

Details and patient eligibility

About

This study aims to compare ultrasound-guided subtransverse process interligamentary (STIL) block versus thoracic paravertebral block (TPVB) for postoperative analgesia in patients undergoing open nephrectomy.

Full description

Acute pain physiopathology is explained as it is mediated by inflammatory cell infiltration, activation of spinal cord pain pathways, and also by reflexive muscle spasm. All of these three mechanisms of acute pain are typically ameliorated during the postoperative recovery.

A thoracic paravertebral block (TPVB) shows comparable analgesic efficacy with fewer side effects compared with thoracic epidural analgesia in patients undergoing thoracotomy.

The recently introduced subtransverse process interligamentary (STIL) block offers a safer alternative by targeting thoracic nerves without entering paravertebral space.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 65 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-III.
• Undergoing open nephrectomy under general anesthesia.

Exclusion criteria

• History of allergies to local anesthetics.
• Opioid dependency.
• Bleeding or coagulation disorders.
• Psychiatric and neurological disorder.
• Local infection at the site of injection.
• Body mass index (BMI) > 35 kg/m2.
• Severe heart, lung, liver, and renal dysfunction.
• Pregnant or lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

70 participants in 2 patient groups

STIL group

Experimental group

Description:

Patients will receive subtransverse process interligamentary (STIL) block using 20ml of bupivacaine 0.25%.

Treatment:

Other: Subtransverse process interligamentary

TPVB group

Experimental group

Description:

Patients will receive a thoracic paravertebral block (TPVB) using 20ml of bupivacaine 0.25%.

Treatment:

Other: Thoracic paravertebral block