Ultrasound Guided TAP Block for Postoperative Analgesia After Abdominal Surgery. (TAB)

Assiut University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Postoperative Pain

Treatments: Drug: Bupivacaine 0.25% 20ml on each side Sonar guided TAB; Drug: Morphine 15mg; Drug: Morphine 10mg

Study type: Interventional

Funder types: Other

Identifiers

NCT02976597

17100234

Details and patient eligibility

About

Transversus abdominis plane (TAP) block is a novel type of peripheral nerve block that involves innervations of the anterolateral abdominal wall derived from T6-L1.It provides adequate post-operative pain relieve following the various abdominal surgeries. Theoretically, TAP block may replace the need for epidural analgesia after abdominal operations. The oblique subcostal approach of the TAP (OSTAP) block, which was de¬scribed by (Hebbard et al, 2010) , has been reported to provide analgesia to the entire anterior abdomen.

Full description

The transversus abdominis plane (TAP) technique, originally described by involves injection of local anaesthetic in the plane between the internal oblique and transversus abdominis muscle layers, with the aim of anaesthetising the intercostal nerves supplying the abdominal wall. Initially, the block used surface landmarks of the triangle of Petit (latissimus dorsi posteriorly, external oblique superiorly, iliac crest inferiorly) and a double fascial 'pop' (loss of resistance) to guide placement of the local anaesthetic. More recently, ultrasonography has been used to guide the delivery of the injectate into the appropriate plane, thereby increasing the accuracy of the Technique.

The duration of the TAB is limited to effect of administered local anesthetics. To prolong the block's duration, adjuvant medications were added to LA to magnify the effect of TAP block . Opiates such as morphine and tramadol have peripheral and central analgesic effects. Opiate receptors are present at the terminals of afferent peripheral nerves; therefore, administration of opiates peripherally might provide a significant analgesic effect.

Enrollment: 90 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

BMI< 30kg/m2.

• Age: 18-60 years.
• Sex: both males and females.
• ASA physical status: 1-II.
• Operation: Abdominal laparotomy.

Exclusion criteria

• Patient refusal.
• History of cardiac disease, psychological disorders, respiratory diseases including asthma, renal or hepatic failure.
• Coagulation disorders.
• Allergy to study medications.
• Chronic use of pain medications.
• Pregnancy.
• Respiratory tract in-fection within the last 2 weeks.
• Heavy smoker.
• Histo-ry of abdominal surgery or trauma.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

90 participants in 3 patient groups

Bupivacaine 0.25%

Active Comparator group

Description:

Bupivacaine 0.25% 20ml will be administered for ultrasound guided TAP block on each side on each side at end of the surgery.

Treatment:

Drug: Bupivacaine 0.25% 20ml on each side Sonar guided TAB

Morphine 10mg

Active Comparator group

Description:

Morphine 10mg and Bupivacaine 0.25% 20ml will be administered for ultrasound guided TAP block on each side at end of the surgery.Patients will recieve 5mg morphine on each side

Treatment:

Drug: Morphine 10mg

Drug: Bupivacaine 0.25% 20ml on each side Sonar guided TAB

Morphine 15mg

Active Comparator group

Description:

Morphine 15mg and Bupivacaine 0.25% 20ml will be administered for ultrasound guided TAP block on each side at end of the surgery. Patients will recieve 7.5mg morphine on each side

Treatment:

Drug: Morphine 15mg

Drug: Bupivacaine 0.25% 20ml on each side Sonar guided TAB