Ultrasound Guided Thoracic Paravertebral Block for Hepatic Tumors Ablation

Mahidol University

Status: Completed

Conditions: Liver Cancer

Treatments: Drug: 0.5% marcaine 20ml

Study type: Interventional

Funder types: Other

Identifiers

NCT02271646

070/2557(EC2)

(IO) R015731063 (Other Grant/Funding Number)

Details and patient eligibility

About

Patients undergo percutaneous radiofrequency ablation of hepatic tumors at Siriraj hospital normally receive only intravenous sedative drugs which sometimes can not provide effective pain control.

TPVB is suitable for unilateral operations. And it is increasing popular nowadays because of using ultrasound guided which make it is more reliable and has less side effects especially the severe one such as pneumothorax. To cover all nerve supply liver, we decided to use right TPVB at T5-6, T7-8, and T9-10.

The aim of this study is to prove that TPVB can provide an effective pain control for patients undergo liver RFA both at rest and movement (cough). We are going to measure the pain score at recovery room and the effective pain control means patients has mild pain (pain score less </= 3 and do not ask for analgesic drugs).

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Patients undergo percutaneous radiofrequency ablation for liver tumors
• ASA classification 1-3

Exclusion criteria

• Psychiatric illness
• Chronic abdominal pain > 1 week
• Regular analgesic drugs use
• Infection at back (Block area)
• Severe spinal deformity
• PT > 16 sec, aPTT > 32, platelet < 50,000/cumm

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

35 participants in 1 patient group

0.5% marcaine 20ml

Experimental group

Description:

3 levels ultrasound guided thoracic paravertebral blocks at T5-6, T7-8 and T9-10 (total 0.5% marcaine 20ml)

Treatment:

Drug: 0.5% marcaine 20ml